How serious are the symptoms of drug eruption?

summary

The severity of drug eruptions varies greatly, from small areas of mild flushing with papules to systemic skin exfoliation. The rash may appear immediately after administration (e.g. wheal after penicillin administration) or after several hours or days. It's very rare to have a drug eruption a few years later. For example, arsenic intake can cause skin scaling, color changes, and even canceration in a few years. How serious are the symptoms of drug eruption? Let's talk about it

How serious are the symptoms of drug eruption?

Fixed erythema type: it is a common type of drug eruption, and its shape is also special. Skin lesions can occur in any part of the body, but often at the junction of skin and mucosa. The lesions are well-defined round or oval erythema, bright red or purplish red, with blisters and bullae in the center. After the inflammation subsided, gray blue or brown pigmentation was left locally. When the same drug is used in the future, it occurs in the same part.

Urticaria and angioedema type: the rash is a wheal of different sizes. Edema of lips, eyelids and prepuce. Different from the general urticaria, the wind mass is common throughout the body, with a large number, bright red color and long duration. Severe itching can be accompanied by tingling and tenderness. It can be combined with serum disease like manifestations, such as joint pain, abdominal pain, diarrhea, lymphadenopathy and so on. Severe cases can be complicated with anaphylactic shock.

Measles like or scarlet fever like type: more common, skin lesions were diffuse bright red, or rice grains to slightly larger red macular, dense symmetry, often from the face and neck to the trunk and limbs spread, is the most common drug eruption, the patient's general condition is good, after 1 week, severe 2-3 weeks, appear chaff like eyebrow. The common drugs were sulfonamides, penicillin, streptomycin, barbital, ampicillin, phenolphthalein, etc.

matters needing attention

Prevent secondary infection of skin and lung, trim hair and toenail in time, clean and disinfect skin every day. Ask the patient not to rub the eyes, so as to avoid the risk of inflammation. Regular skin, oral fungi, bacteria and other tests for patients, and give symptomatic care. Turn over regularly, and use sponge pad or balloon to prevent bedsore. Ask the patient to combine work and rest, forbid smoking and drinking, protect the liver, avoid using liver injuring drugs, such as barbital, hibernating spirit, anthelmintic, etc., and intravenous infusion of glucose injection and vitamin C.