Myasthenia gravis cases

summary

I didn't have myasthenia gravis before I got married. I didn't know what was going on during the Chinese New Year. I felt that I didn't have any strength. I went to the hospital for an examination, but it turned out to be myasthenia gravis. After treatment, I have basically recovered. Now I would like to share with you the problems about myasthenia gravis.

Myasthenia gravis cases

Treatment 1: myasthenia gravis is an autoimmune disease, cholinesterase inhibitors, glucocorticoids, immunoglobulin are commonly used in the treatment of drugs, related studies show that the use of glucocorticoid prednisone oral combined with intravenous immunoglobulin treatment of myasthenia gravis better.

Treatment 2: glucocorticoid has a wide range of regulatory effects on the immune system, and has become one of the main treatment methods in traditional treatment. However, long-term large-scale use of hormone has serious adverse reactions, especially in myasthenia gravis crisis, short-term high-dose pulse therapy can inhibit the release of presynaptic membrane acetylcholine, which may lead to the aggravation of myasthenia gravis. When respiratory muscle paralysis occurs, ventilator should be used.

Treatment 3: immunoglobulin can provide a large number of idiotypic antibodies, which can neutralize pathological autoantibodies and prevent them from acting on autoantigens; at the same time, it can reduce the production of autoantibodies; accelerate the degradation and metabolism of IgG antibodies; inhibit pathological cytokines; regulate the function of T cells and neutralize super antibodies, so as to reduce toxic T cells; and; It can compete or inhibit the binding of antibody circulating immune complex with autoantigen and enhance the inactivation of circulating immune complex. Nicotinic acetylcholine receptor (nAChR) is the antigen that causes autoimmune response in myasthenia gravis. Intravenous immunoglobulin therapy not only improves the clinical symptoms of myasthenia gravis, but also significantly reduces the blood titer of patients after treatment.

matters needing attention

Warm reminder: Patients with myasthenia gravis must pay attention to daily life, get up and rest on time, don't stay up late, pay attention to the combination of work and rest, don't make yourself overworked, avoid aggravating the disease, patients with ocular myasthenia gravis should pay attention not to watch TV for a long time, pay attention to the rest of the eyes.