Can rosacea use tretinoin cream?

summary

Tretinoin cream is used in the adjuvant treatment of acne vulgaris, lichen planus, leukoplakia, pityriasis rubra, keratosis follicularis and psoriasis. It is forbidden for those allergic to vitamin A derivatives. So, can tretinoin cream be used for rosacea patients?

Can rosacea use tretinoin cream?

One of the significant pharmacological activities of tretinoin cream is to induce epidermal proliferation. Tretinoin cream can thicken the granular layer and spinous cell layer. DNA synthesis and mitotic index of epidermal cells can be seen to increase. The effect of tretinoin cream is to promote the differentiation of epidermal granular layer cells into stratum corneum by affecting the hydrolysis of K1 and K10 keratinases at the late stage of differentiation of epidermal cells. Tretinoin cream can affect the process from mitogen to fibronectin and the formation of cross-linking capsule. Tretinoin cream can significantly inhibit the formation of experimental acne. Tretinoin cream can remove the keratin plug by regulating the abnormal keratinization process of hair follicle sebaceous gland epithelium, so as to prevent and eliminate acne lesions.

Tretinoin cream can affect the formation of melanin in melanocytes. Tretinoin cream can inhibit the activities of tyrosine hydroxylase, dopa oxidase and dihydroxyindole oxidase. Tretinoin cream can reduce the formation of melanin and reduce skin pigmentation. Retinoic acid cream had no effect on tyrosinase activity and melanin composition of normal human melanocytes.

When the skin is physiologically aged, or injured by drugs, ultraviolet radiation and trauma, retinoic acid cream can correct or prevent the abnormal biochemical composition and morphological structure of dermal connective tissue caused by harmful factors, It can also improve the tension strength of the wound. Retinoic acid cream had no effect on collagen synthesis of normal skin. Tretinoin cream has inhibitory effect on leukocyte chemotaxis, so it has anti-inflammatory effect.

matters needing attention

If you have more questions about this product, or any other questions about the use of this product, it is suggested that patients should have a detailed understanding of the drug contraindications, adverse reactions, interactions, etc. in order to achieve safe, reasonable, effective and economical use of this product, drug selection should be careful, please use it under the guidance of professional doctors or licensed drugs.