Can Turner syndrome be treated by Datong?

summary

Depression is the most common mental disease in adolescents, which brings great harm to patients. Although adolescents with Turner's syndrome will bear more pressure in puberty due to their short stature, barreled chest, low hairline, low ears, webbed neck and other physical characteristics, their depression has not received enough attention. Now let's talk about Turner's syndrome. Can Datong be treated?.

Can Turner syndrome be treated by Datong?

First: Turner's syndrome is a disease that has no effective treatment at present. This disease can lead to mental development damage, but the intelligence of some patients can also be normal. After the disease, some people are prone to lower extremity lymph node edema, or renal dysplasia, and can lead to aortic arch stenosis. Patients with Turner's syndrome have lower bone mineral density than normal people.

Second: short stature affects students' participation in study and multiple types of work, affects their later life, and is subject to undue discrimination in society, causing serious concern to patients and their families. There are still controversies about how to improve height. It is suggested to use androgen to promote height, but the effect is not obvious when the dosage is small. Although the dosage is large, it is effective, but the side effects are great, mainly for masculinity and impaired glucose tolerance; Estrogen alone is easy to cause early healing of growth plate, thus limiting bone growth and inhibiting growth potential. The application time of estrogen is very critical, generally not before 12 years old, preferably after 15 years old.

Third: some people think that estrogen can improve self-image, emotion and cognitive ability, and make the height reach the best, but the initial dose needs to be very low. With androgen to promote height, should be used after 8 years old, generally around 11 years old. Before epiphyseal healing, in order to increase height, Beijing Union Medical College Hospital used to inject norone propionate 25mg intramuscularly once every two weeks for 3-6 months. After stopping the drug for half a year, 28 cases of nonunion of epiphyseal could be treated repeatedly. Due to the small number of cases, it is difficult to compare the age, time and dosage of the drug. There were 8 patients over 17 years old, 1 case increased by 7.5cm (125.5-143.0cm), 2 cases increased by 11.0cm, 3 cases increased by 7.0cm, 2 cases increased by 4.0cm and 2.0cm at 19 and 20 years old. In recent years, tibolone, a drug containing estrogen, pregnancy and androgen, has been used in the treatment of Turner's syndrome. After short-term and long-term treatment with tibolone, 7 cases of Turner achieved positive height growth. The preliminary results showed that the height of Turner increased by 0.5-3.0 cm after 3 months of treatment with tibolone, Average growth (2.2? 1.4)cm。 After 24-36 months of treatment, the height increased by 6.5-12.5cm, with an average increase of (9.6 ± 1.5) cm? 7) cm (Tian Qinjie, 2002), which was higher than that of growth hormone therapy alone (5.3 cm on average), estrogen plus androgen therapy (3 cm on average) and estrogen plus androgen plus growth hormone therapy (3 cm on average), which was similar to that of androgen plus growth hormone therapy (8.5 cm on average)? 6) cm]. The good effect of tibolone (Livial) treatment may be to simulate the hormone changes at the onset of puberty to some extent, or stimulate the production and secretion of GH through its androgen and estrogen, and then exert its growth promoting effect through the action of IGF-I on bone. Its mechanism needs further study. Because of the convenience of oral administration, it is a promising treatment. Due to the small number of cases, further observation is needed.

matters needing attention

1. Food rich in estrogen should be eaten; 2. Food rich in protein and zinc should be eaten; 3. Eat high sugar food.