Is prion painful?

summary

There are many diseases around us that we don't know. We haven't heard of prion disease for many times. We won't be involved in these diseases in most cases. But are there still a few people suffering from prion disease? Now let me tell you something.

Is prion painful?

The pathogen of this disease is an infectious protein, prion, which is translated as prion protein or infectious protein. Although some scholars think that PRP may contain a very small amount of nucleic acid (< 50 nucleotides), it is still uncertain whether PrP contains nucleic acid, so it does not belong to the scope of virus. It can resist the decomposition of high heat, nuclease and ultraviolet, but a variety of proteases, protein denaturants, detergents, organic solvents and urea can reduce its infectivity, indicating that protein is the core component of infection.

Prion disease is a group of infectious, chronic progressive and fatal spongiform encephalopathy caused by mutated prion protein. Prion disease was first found in animals. It was discovered 200 years later that prion disease can occur in human beings. There are four kinds of prion diseases in human and animal.

Its core is a 27-30kd protein, which is called prp27-30. The core of this thermostable protease is covered with a protein with a molecular weight of 33-35kd, called prp33-35 or PrPSc. Another protein similar to PrPSc, PrPc, is found in the brain of uninfected normal animals. It can tolerate protease digestion and polymerize into a rod-shaped structure called PrP rod or pruritus associated filaments (SAF).

matters needing attention

Sometimes, we all have a headache about why we are suffering from diseases, and we know nothing about the diseases we are suffering from. Only with a better understanding of our diseases can we do the following. So it's very important for us to understand the disease. Let's start with prion disease.