Can hydrothorax lead to elevated CA125

Update Date: 2021-04-12 Source: Network

summary

The increase of CA125 may cause cancer for patients. In fact, the increase of CA125 may not only cause cancer, but also some other symptoms. That is to say, it may not be cancer that causes the increase of CA125. Let's talk about whether pleural effusion can cause the increase of CA125.

Can hydrothorax lead to elevated CA125

First, the differentiation of benign and malignant pleural effusion needs to be measured by a comprehensive number of indicators, not just a few indicators. Pleural effusion routine can only identify exudate and leakage, but not benign and malignant. Currently, the commonly used methods for the differentiation of benign and malignant pleural effusion are: Ada, LDH, CEA, CA50, CA125, CA19-9, β 2-mg, NSE, CK19, T cell subsets, chromosome examination, DNA flow cytometry, exfoliated cells Pleural biopsy, thoracoscopic biopsy, etc.

Second, many studies at home and abroad have shown that the abnormal increase of serum CA125 level is associated with TNM stage and pleural effusion of lung cancer. Dynamic monitoring of serum and pleural fluid CA125 is helpful for the diagnosis of non-small cell lung cancer in different stages. Clinical dynamic monitoring of CA125 is often used as a reference index for clinical efficacy observation and prognosis judgment.

Third: CA125 comes from fetal coeloma epithelial tissue and exists in serum as a group. It is a group of high molecular glycoproteins synthesized in cells and stored in cells. Under normal circumstances, CA125 cannot enter into serum due to the connection between cells and the blocking effect of basement membrane. Therefore, CA125 can not be detected in normal human serum or its concentration is very low.

matters needing attention

In addition to the fact that the cause of cancer can lead to the increase of CA125, there are many other reasons in life that can lead to the increase of CA125 content. That is to say, if the increase of CA125 is found in the examination, don't worry too much that it is cancer. Just find out the cause carefully, and it may not be cancer.