What effect does hyperthyroidism have on the heart

summary

Hyperthyroidism is a common medical disease, the occurrence of this disease has brought many threats to the health of patients. Hyperthyroidism may also affect the patient's heart, after the heart is affected, the patient's health will be more damaged. However, most patients do not understand this knowledge. Here's how hyperthyroidism affects the heart.

What effect does hyperthyroidism have on the heart

1. When it comes to the effects of hyperthyroidism on the heart, we have to mention thyroxine. Thyroxine can directly or indirectly affect the heart by increasing the metabolic rate of the whole body, resulting in changes in the structure and function of the heart. Thyroxine acts on cardiac β - adrenergic receptor, activates adenylate cyclase on myocardial cell membrane and increases intracellular cAMP.

2. Thyroxine also acts directly on the adenylate cyclase in the myocardial meninges. It can promote the activity of ATPase and myosin ATPase, increase the density of β - adrenergic receptor on myocardial cell membrane, and enhance the sensitivity to catecholamine. Therefore, thyroxine has positive chronotropic, inotropic and variable speed effects on the heart. In the early stage, it can lead to the increase of heart rate, cardiac contractility, cardiac output, cardiac myocyte globulin synthesis and cardiac myocyte hypertrophy.

3. The long-term effect of thyroxine on myocardium can lead to the gradual weakening of myocardial contractility and heart failure. Clinical symptoms of hyperthyroidism, such as fear of heat, sweating, finger tremor, emotional excitement, hyperappetite, overeating, emaciation, diffuse goiter, can be accompanied by exophthalmos. When hyperthyroid heart disease is caused, sinus tachycardia often occurs. Due to the strengthening of myocardial contractility, the first heart sound in the apical region can be enhanced and the heart expands. If the left ventricle is enlarged, the systolic blowing noise can be heard in the apical region.

matters needing attention

The above content introduces the impact of hyperthyroidism on the heart. In fact, patients with hyperthyroidism should not worry too much. The psychological pressure is relatively large, which is not conducive to the treatment of the disease. Therefore, after suffering from hyperthyroidism, we should adjust our mentality, receive treatment as soon as possible, and check our condition regularly.