What is the reason for the high incidence of Behcet's disease?
summary
Behcet's disease is very common. Of course, many patients don't know what Behcet's disease is, and they don't even know that they have Behcet's disease. Behcet's disease usually occurs in oral and external ulcers, characterized by inflammation of the eyes and multiple damage to the skin. What causes Behcet's disease is a concern of many patients, Now we invite oral mucosa experts to make a detailed introduction for you.
What is the reason for the high incidence of Behcet's disease?
1. In the early stage, the virus was considered as the cause of the disease, but it was not further confirmed by epidemiology, tissue culture, serology, animal inoculation, immunofluorescence and electron microscopy. According to the report of washing and dyeing, the disease may be related to autoimmune abnormality caused by lentivirus infection; Some reports also found evidence of the relationship between HSV-1 and the disease, such as the evidence of the relationship between anti HSV-1 in human blood and the disease, such as the increase of anti HSV-1 antibody titer in human blood, the immune abnormality caused by the influence of HSV-1 on CD4 lymphocytes, and the homologous DNA of HSV-1 with peripheral blood lymphocytes.
2. Because some people often have tonsillitis, pharyngitis, periodontitis and other diseases, it is believed that the incidence of Streptococcus is related to the bacteria in these lesions. It was found that the titer of anti streptococcal antibody in patients' serum increased; Among the strains isolated from human oral cavity, streptococcus is the most closely related, especially s. sanguinis. The positive results can be obtained by intradermal test and macrophage migration inhibition test; The 65 kDa heat shock protein test of Streptococcus can cause skin hypersensitivity and systemic symptoms. These studies were mainly carried out by Japanese scholars. Although they thought that they played an important role in the pathogenesis, they did not reach a consistent conclusion.
3. Since 1964, tuberculosis has been reported in China, which is related to tuberculosis infection. That is to say, before the initial damage of behct's disease, tuberculosis has occurred, such as pulmonary tuberculosis, lymphoid tuberculosis and other tuberculosis lesions. It can be old lesions, but most of them are active lesions. Most ot tests were strongly positive; Antituberculosis drugs not only have obvious effect on the primary lesion, but also improve the related damage of Behcet's disease, so it is considered as an allergic manifestation of tuberculosis. The 65 kDa heat shock protein of Mycobacterium tuberculosis is also related to the occurrence of this disease.
matters needing attention
The earlier Behcet's disease is found and treated, the better the effect will be. Without treatment, serious patients may even die. Moreover, there is no preventive medicine or method for this kind of disease in current medicine, so early treatment is the most critical link.
