What are the causes of alcoholic liver disease

summary

Alcoholic liver disease is more and more appearing in people's life, which brings a lot of inconvenience to people's life. Many people are more concerned about the factors causing alcoholic liver disease. As the name suggests, the main reason is the disaster caused by alcohol. In fact, alcoholic liver disease caused by long-term excessive drinking is not only the factor of drinking, but also many other factors. Let's take a look.

What are the causes of alcoholic liver disease

Reason 1: alcohol is the direct cause of alcoholic liver disease. Liver disease experts say that regular drinking can cause liver damage, and the damage mechanism is caused by the metabolism of alcohol in liver cells. Under the action of alcohol dehydrogenase and microsomal alcohol oxidase system, alcohol entering into hepatocytes is transformed into acetaldehyde, and then into acetic acid. The increase of the ratio of reducing coenzyme I (NADH) to reactive coenzyme I (NAD) can inhibit the mitochondrial tricarboxylic acid cycle, cause the disorder of fatty acid metabolism in liver, weaken the oxidation, and cause the accumulation of neutral fat in hepatocytes. Thus, alcoholic liver is formed.

Reason 2: in view of the problem of "what are the causes of alcoholic liver disease", experts said that heavy drinking damages oxidative phosphorylation and fatty acid beta oxidation in the body, and increases free fatty acids in blood and liver cells. Alcohol can specifically increase the demand for choline, and choline is one of the raw materials for the synthesis of phospholipids, and phospholipids is an important raw material for the synthesis of lipoprotein, so the lack of phospholipids affects the synthesis of lipoprotein, thus affecting the smooth transportation of fat from the liver to form fatty liver.

Reason 3: through the analysis of the pathogenesis of alcoholic liver, it is found that a large amount of alcohol produced by drinking will stimulate the adrenal gland and pituitary adrenal axis, thus increasing the decomposition rate of adipose tissue. The fatty acids derived from this will be absorbed by the liver, increasing the synthesis rate of triglyceride in the liver and accumulating, and the secretion of very low density lipoprotein (VLDL) will be hindered due to the lack of apolipoprotein, resulting in fatty liver .

matters needing attention

There are many factors causing alcoholic liver disease, in order to accurately determine the cause, we understand the factors of alcoholic liver disease. It can be seen that there are many inducing factors of alcoholic liver disease, so we should be comprehensive in the prevention of alcoholic liver disease in our life, develop good living habits, pay attention to hygiene, reduce the pressure of life, and always keep a happy mood. The most important thing is to stop drinking, and to stay away from alcoholic liver disease is the most important choice.