What reason is white spot appeared on leg

summary

Suddenly I found some small white spots on my legs. I was especially afraid of skin diseases. So went to the hospital to see, the doctor said that this is vitiligo, we must take some treatment as soon as possible, otherwise it will spread. Next, I'll tell you why there are white spots on the legs?

What reason is white spot appeared on leg

First: vitiligo can appear in twins and families, indicating that heredity plays an important role in the pathogenesis of vitiligo. Studies have shown that vitiligo has incomplete penetrance and multiple pathogenic loci. Vitiligo can be combined with autoimmune diseases, such as thyroid disease, diabetes, chronic adrenal insufficiency, pernicious anemia, rheumatoid arthritis, malignant melanoma and so on.

Second, specific antibodies of various organs can be detected in serum, such as anti thyroid antibody, anti gastric parietal cell antibody, anti adrenal antibody, anti parathyroid antibody, anti smooth muscle antibody, anti melanocyte antibody, etc. Mental factors are closely related to the onset of vitiligo. Most patients have mental trauma, excessive tension, depression or depression at the onset or skin lesion development stage. The degeneration of nerve endings in leukoplakia also supports the neurochemical theory.

Third: the body of vitiligo patients can produce antibodies and T lymphocytes, which indicates that the immune response may lead to the destruction of melanocytes, and the toxic precursors of melanocytes synthesized by cells themselves and some chemical substances leading to skin discoloration may also selectively destroy melanocytes. The decrease of copper or ceruloplasmin levels in the blood and skin of patients with vitiligo leads to the decrease of tyrosinase activity, which affects the metabolism of melanin.

matters needing attention

In fact, suffering from vitiligo can be caused by many factors, some doctors will say that vitiligo and genetic, or the lack of melanin in some patients, so it will cause white spots on the skin. Such patients go out to do protective measures, do not let the skin by sunlight, and then light diet.