What reason is pregnant child undeveloped?

summary

From the medical point of view, fetal arrest refers to the death of an embryo at a certain stage of its development and its continued development. A fertilized egg is like a seed. It has to go through a series of complex and wonderful processes before it finally grows into a healthy baby. What reason is pregnant child undeveloped? Let's talk about it.

What reason is pregnant child undeveloped?

The embryo or fetus of immune factor pregnancy is allogeneic transplantation, because the fetus is the combination of parents' genetic material, and it can not be exactly the same as the mother. Maternal fetal immune maladjustment causes maternal rejection of the fetus. The common autoimmune diseases are systemic lupus erythematosus, scleroderma, mixed connective tissue disease and dermatomyositis. The second is the problem of reproductive immunity. If we carry certain antibodies, it may affect the development of embryos. In fact, the detection of antibodies varies from hospital to hospital, and the views of doctors are also different. From our research point of view, we think that there are four influencing factors. One is antisperm antibodies. If there are any, they may resist sperm egg binding; The second is anti endometrial antibody. If anti endometrial antibody exists, it may affect the development of embryo and resist the development of embryo; The third is anti ovarian antibody, if you want to have it, it will affect the quality of the egg; The fourth is called anti chorionic gonadotropin antibody. This hormone is actually an important hormone secreted seven days after sperm egg combination. However, if you have this antibody, you will resist the secretion of hormone, which may cause embryo abortion.

Abnormal uterus, the internal environment of the uterus and the overall environment of the uterus may have an impact on the embryo. The internal environment is the endometrium. If it is too thin or too thick, it will affect the implantation. The common causes of abortion are (1) congenital abnormalities of mullerian duct, including single horn uterus, double uterus, septal uterus and double horn uterus, resulting in narrow uterine cavity and limited blood supply. Abnormal uterine artery development can lead to dyssynchrony of decidualization and abnormal implantation（ 2) Intrauterine adhesions are mainly caused by intrauterine trauma, infection or residual placenta tissue. It hinders normal decidualization and placental implantation（ 3) Uterine fibroids and endometriosis lead to blood supply reduction, leading to ischemia and venous dilation, dyssynchrony of decidualization, abnormal implantation and hormone changes caused by fibroids can also lead to pregnancy failure. (4) congenital or traumatic cervical relaxation and intrauterine treatment with diethylstilbestrol often lead to mid-term pregnancy abortion.

Chromosomal problems, if abnormal, can also lead to early abortion due to embryonic underdevelopment. Chromosome abnormalities include quantitative and structural abnormalities, which can be divided into aneuploid and polyploid. The most common abnormal karyotype is triploid, and trisomy 16 accounts for 1 / 3, which is often fatal. 25-67% of trisomy 21, 4-50% of trisomy 13 and 6-33% of trisomy 18 were inevitable abortion. The others are haploid (4sx), tetraploid, and embryo undevelopment due to abnormal cleavage. There are structural abnormalities, such as loss, balance translocation, inversion, overlap, etc. Balanced translocation is the most common chromosome abnormality. On the chromosome problem, the current studies suggest that the pairing, exchange and separation of chromosomes form gametes, and gametes combine to form zygotes. If the zygote is abnormal, it will lead to abnormal development, which can lead to abortion, stillbirth, stillbirth and malformation. Therefore, prenatal diagnosis is needed to prevent the birth of children with chromosome. At present, western medicine has no effective treatment for abortion and fetal arrest caused by chromosome abnormality, only prenatal genetic counseling and diagnosis can be carried out. Theoretically speaking, there is a chance to give birth to normal karyotype and carrier babies. Prenatal diagnosis should be made for these couples to ensure normal birth. Of course, current studies also show that both couples have normal chromosomes, but there are chromosomal abnormalities during gametogenesis and embryo development. If the female is older than 35 years old and the egg is aging, it is easy to have chromosome non separation, leading to chromosome abnormalities; Semen abnormalities, such as macrocephaly sperm are mostly diploid, the formation of polyploid embryos after fertilization, leading to abortion. Adverse environmental effects such as toxic chemicals, radiation and high temperature can also cause chromosomal abnormalities in embryos. Therefore, the key to prevent fetal arrest due to chromosomal abnormalities is to regulate the body of both husband and wife, make their viscera function normal coordination, balance yin and Yang, choose the best and get pregnant, and stay away from the bad environment.

matters needing attention

Fetal underdevelopment is not without reasons. If mothers can not protect themselves, it will affect the development of the fetus. Therefore, mothers hope that their fetus will grow healthily. They must not continue to do something harmful to their health. They should keep in a good mood, enjoy a good environment, stay away from radiation and refuse to get pregnant.