What causes nephrotic syndrome in children?

summary

Nephrotic syndrome in children is a common renal disease in children. The cause of nephrotic syndrome is that the glomerular filtration membrane has increased permeability to plasma protein, and a large amount of albumin is lost from urine, resulting in a series of pathophysiological changes. What causes nephrotic syndrome in children? Let's talk about it

What causes nephrotic syndrome in children?

Primary: that is, the original lesions in the glomerular disease, according to the current domestic clinical classification, primary glomerular disease, acute glomerulonephritis, progressive glomerulonephritis, chronic glomerulonephritis and glomerulonephritis can appear in the process of the disease. Pathologically, small lesions, focal segmental glomerulosclerosis, membranous nephropathy, membranous proliferative glomerulonephritis, lipoprotein glomerulopathy, collagen III glomerulopathy, fibrous glomerulopathy and collapsible glomerulopathy are the main manifestations of the disease. Mesangial proliferative glomerulonephritis can also occur in children with nephrotic syndrome.

Nephritic nephropathy: in addition to typical symptoms, it also has one of the following characteristics, including hypertension [preschool children, blood pressure higher than 16 / 10.7kpa (120 / 80mmHg), school-age children higher than 17.3 / 12kpa (130 / 90mmHg)]; Hematuria (more than 10 red blood cells / HP detected by centrifugal uroscopy); Azotemia (BUN > 10.7 mmol / L, > 30 mg / dl) and persistent hypocompleminemia.

Congenital nephrosis: onset after birth or shortly after birth (<2 months after birth) incidence rate, presenting the above typical symptoms, family history, low birth weight (multiple premature infants), intrauterine asphyxia, meconium stained amniotic fluid, breech presentation and large placenta are all helpful to the diagnosis of this disease. The incidence of this disease is high in Finland, rare in China, no response to hormone or poor response. Most of them died of infection, renal failure or other complications within 6 months after birth.

matters needing attention

During the epidemic period of infectious diseases, parents should avoid taking their children to public places and crowded places, so as not to aggravate children's nephrotic syndrome. Through simple labor to cultivate good habits. Increase the amount of exercise. Moderate physical exercise and perseverance.