Symptoms of trophoblastic tumor?

summary

Trophoblastic tumor, also known as trophoblastic disease; Trophoblastic tumor; Trophoblastic tumor; Trophoblastic tumor; Ulcerative islet cell tumor; Gastrinoma; Tumor cells can secrete gastrin; Trophoblastic tumor refers to the malignant transformation of embryonic trophoblast. The first is divided into two types, one benign is called "hydatidiform mole", the other malignant is called "choriocarcinoma". Later found between the two, there is a form like hydatidiform mole, but with a certain degree of malignancy, can invade the muscular layer or metastasis to distant. So what are the symptoms of trophoblastic tumors?

Symptoms of trophoblastic tumor?

The symptoms of benign hydatidiform mole are often similar to pregnancy, with amenorrhea and pregnancy reaction. But the pregnancy reaction is often earlier than normal pregnancy and obvious, amenorrhea 6-8 weeks began to appear irregular vaginal bleeding, the initial amount of bleeding is less, dark red, from time to time, gradually increasing, continuous, so patients often appear varying degrees of anemia. When hydatidiform mole is to be discharged by itself (usually in about 4 months of pregnancy), massive hemorrhage can occur, and the treatment is not timely, which can lead to shock and even death. Sometimes transparent grape like substance can be seen in the discharged blood. If it is found, it is very helpful for the diagnosis.

In about 10% of patients, in addition to hyperemesis gravidarum, there may be proteinuria, edema, hypertension and other hypertensive disorders during pregnancy, and even eclampsia, convulsions and coma. Heart failure also occurs. Due to normal pregnancy, pregnancy induced hypertension rarely occurs before 20 weeks of gestation. If it occurs, hydatidiform mole should be suspected. Sometimes the patient may also have a panic and shortness of breath.

Abdominal pain is not common in hydatidiform mole, even if there is acute abdominal pain, mainly occurs in the abnormal enlargement of the uterus of primipara, but when the hydatidiform mole will be discharged, there may be paroxysmal abdominal pain due to uterine contraction, which is often accompanied by increased bleeding. If there is no acute abdominal pain at the time of discharge, complications should be considered. There was no obvious pulmonary metastasis in hydatidiform mole patients, but hemoptysis occurred. Hemoptysis disappeared immediately after hydatidiform mole was discharged.

matters needing attention

In addition to some early cases, the lesions were limited to the uterus, and some patients without metastasis could survive. Almost all patients with metastasis died within 6 months after diagnosis, and the total mortality was more than 90%. In order to improve the curative effect, postoperative radiotherapy has a certain synergistic effect on some parts of the tumor, but for later cases, the curative effect is still very poor.