What can cause creatinine high

summary

High creatinine represents decreased glomerular filtration rate and renal detoxification. With the continuous increase of creatinine index, the degree of renal function damage will be more and more serious. Therefore, once the diagnosis of high creatinine, we should pay attention to treatment, alert to the harm of high creatinine to human body. What can cause creatinine high? Let me talk to you today.

What can cause creatinine high

First, for creatinine, in muscle, creatine mainly forms creatinine slowly through irreversible non enzymatic dehydration reaction, which is then released into the blood and excreted with urine. Therefore, serum creatinine is closely related to the total amount of muscle in the body and is not easily affected by diet and urine volume. When the renal function is not complete, creatinine accumulates in the body and becomes a harmful toxin.

Second, the normal upper limit of serum creatinine is about 100 μ molgl. Renal patients in clinical examination will appear in the fluctuation of creatinine, performance for blood creatinine is higher than normal, and urine creatinine is lower than normal.

Third: the high serum creatinine is due to the renal invasion of various causes. First, the damaged inherent cells of the kidney undergo phenotypic transformation, forming pathological changes, stimulating the fibroblasts in the kidney to transform into myofibroblasts. At the same time, it also invades and stimulates the inherent normal renal tissues, causing the same pathological changes, thus forming the kidney from point to surface, from local to the whole, expanding During the spreading process of large excitation, it entered the organic damage stage (i.e. renal function damage stage). At this time, due to the continuous damage of the kidney, the function of excreting waste is reduced, resulting in the accumulation of creatinine and other toxins in the body, resulting in the increase of blood creatinine and urea nitrogen, the decrease of urine creatinine, and the decrease of bilateral renal filtration rate. At the same time, patients will have high blood pressure, high edema and other physical symptoms.

matters needing attention

In life, many people are deeply troubled by high creatinine, which brings a lot of influence to people's body and daily life, and even leads to the occurrence of many diseases.