Why do you get diabetes

summary

My grandfather has been suffering from diabetes. He has symptoms of thirst and weight loss, and he has been ill for a long time. Then, why did he get diabetes? Let's give you a brief introduction.

Why do you get diabetes

Etiology 1, genetic factors, which is also one of the most direct causes of disease, generally there will be familial conditions, the general elderly have diabetes, the probability of the next generation is particularly high, there are at least 60 kinds of clinical genetic syndrome can be accompanied by diabetes. There are many DNA loci involved in the pathogenesis of type 1 diabetes, among which DQ polymorphism is the most closely related. A variety of gene mutations have been found in type 2 diabetes, such as insulin gene, insulin receptor gene, glucokinase gene, mitochondrial gene and so on.

Second, environmental factors, obesity caused by excessive eating and reduced physical activity are the main environmental factors of type 2 diabetes, which makes individuals with genetic susceptibility to type 2 diabetes easy to develop. Patients with type 1 diabetes have abnormal immune system. Some viruses, such as coxsackievirus, rubella virus, parotid virus, lead to autoimmune reaction and destroy insulin beta cells.

Obesity is an important cause of diabetes. Especially easy to cause type 2 diabetes. Especially abdominal obesity. The main mechanism is that obese people have obvious hyperinsulinemia. Hyperinsulinemia can reduce the affinity between insulin and its receptor, resulting in the inhibition of insulin action and insulin resistance. This requires islet β - cells to secrete and release more insulin, which in turn leads to hyperinsulinemia. This is a vicious circle of glucose metabolism disorder and β - cell dysfunction, which eventually leads to a serious defect of β - cell function, leading to type 2 diabetes.

matters needing attention

When you have diabetes, you should control your blood sugar well, mainly in your daily diet. You can't eat too much, and you should eat less and more meals, and try not to eat too sweet food.