How is infantile nephroblastoma caused?

summary

Nephroblastoma is the most common malignant tumor in children's urinary system. It is a mixed tumor of embryonic malignancy. Its incidence is second only to neuroblastoma, also known as nephroblastoma, nephroblastoma and mixed tumor of kidney. Rance first described the tumor in 1814. How is infantile nephroblastoma caused? Next, I'd like to share my views with you.

How is infantile nephroblastoma caused?

Nephroblastoma may be caused by abnormal proliferation of metanephric germ with undifferentiated tubules and glomeruli. Nephroblastomatosis complex may also be a precancerous lesion of Wilms. In recent years, it has been confirmed that the deletion of tumor suppressor genes WT1 and WT2 is related to the occurrence of some nephroblastoma.

Nephroblastoma originates from embryo, develops in the renal parenchyma, distorts in the process of growth, and invades the surrounding renal tissue. Almost all renal tumors in children belong to this category. Many undifferentiated tissues can be seen in the pathological section. Sometimes the tumor breaks through the capsule and invades the diaphragm, adrenal gland and colon. Tumor tissue was found in renal vein in 10% - 45% of surgical specimens.

The etiology of nephroblastoma is still unknown. There is a certain familial tendency of nephroblastoma, and the incidence rate is 1% - 2%. Some people think that there is heredity, a few children can have the growth of this tumor; Schweisguth reported that in 600 cases, 5 pairs were brothers and sisters. Xinhua Hospital also met two brothers who had grown the tumor, and a young father who had undergone unilateral nephroblastoma surgery when he was young. His son also developed nephroblastoma when he was 3 years old. It was also reported that three pairs of twin brothers suffered from the disease.

matters needing attention

The diet should be light, pay attention to hygiene, and match the diet reasonably. To avoid the invasion of harmful substances (cancer promoting factors) is to help us avoid or as little as possible exposure to harmful substances. Improving the body's immunity against tumor can help improve and strengthen the body's immune system to fight against tumor.