Where to treat proliferative pemphigus good?

summary

Proliferative pemphigus is a rare benign type of pemphigus vulgaris. Patients are generally young people with low immunity. Skin lesions are mainly located in armpit, breast, groin, vulva, anus, nasolabial groove and limbs. Where to treat proliferative pemphigus good? Next, I'd like to share my views with you.

Where to treat proliferative pemphigus good?

The initial dose of prednisone was 120-180 mg / d; Or 60-100mg / D, the initial dosage can be decreased until no new damage occurs for 1-2 weeks, 5mg for each time, once in 1-2 weeks. When the dosage is lower than 30mg / D, the dosage should be reduced carefully until 10-15mg per day is the maintenance dosage. For patients with severe pemphigus, pulse therapy and intermittent administration can be selected. That is to say, large dose of adrenocortical hormone was given until the patient's condition was stable (about 10 weeks), gradually reduced to 30 mg / D of prednisone, and then given every other day or three days, with a rest of four days.

Corticosteroids: prednisolone or prednisone 40-60mg / day is mainly used. Hydrocortisone 300mg intravenous drip can also be used depending on the condition. After the condition is controlled, the drug is reduced slowly in a planned way. Until the maintenance dose of prednisolone or prednisone is 10-15mg / day.

Plasmapheresis: the purpose of this therapy is to remove the abnormal protein components in patients' plasma, especially antibodies, immune complexes and other harmful non-proliferation substances, and replace them with fresh plasma, fresh frozen plasma or albumin preparation of healthy people. This therapy is a supplementary therapy for patients with side effects caused by corticosteroids. 1 000 ml / day, 3 consecutive days as a course of treatment, 1 course of treatment every week, 3 consecutive courses.

matters needing attention

1. Keep the mattress clean, flat, large area of skin lesions, all kinds of cloth are used after disinfection. 2. Ultraviolet disinfection once a day, 30 minutes - 1 hour each time. 3. Trim the patient's nails to avoid scratching the blister wall.