How to diagnose congenital factor X deficiency?

summary

Congenital factor X deficiency is rare in daily life, mostly due to recessive chromosome inheritance, and the parents of patients are often close relatives. Both men and women may suffer from congenital factor X deficiency. Factor X involves the function of internal and external coagulation system, and may also have similar symptoms of factor VII deficiency. The degree of bleeding is related to the concentration of factor X. Most homozygotes have bleeding symptoms. The treatment of congenital X-factor deficiency is mainly to supplement factor X. the following is mainly about how to diagnose congenital X-factor deficiency.

How to diagnose congenital factor X deficiency?

Congenital factor X deficiency needs to be diagnosed according to clinical bleeding symptoms, genetic type and laboratory examination, and then the diagnosis can be confirmed by FXI: C determination or Biggs thromboplastin production test. Congenital factor X deficiency needs to be distinguished from other hemorrhagic diseases with normal thrombin time and prolonged partial thrombin time.

The diagnosis of acquired FXI deficiency must be different from that of vitamin K deficiency. Hepatobiliary disease and warfarin also have symptoms of factor X deficiency. However, in the above cases, the decrease of FX is secondary, and there will be other vitamin K-dependent coagulation factor deficiency at the same time.

Generally, through detailed examination, congenital X factor deficiency can be diagnosed, and then we must ask the history in detail. In patients with amyloidosis, independent acquired coagulation factor X deficiency can also be found, which may be related to the absorption of FX by amyloid protein.

matters needing attention

In congenital factor X deficiency, replacement therapy was used to solve the bleeding symptoms. General minor bleeding does not need treatment. Mortality from bleeding is very low. Patients with slight bleeding recover quickly. At present, traditional Chinese medicine is unable to treat congenital factor X deficiency.