What are the tests for Parkinson's disease?

summary

Parkinson's disease is a disease that endangers the health of middle-aged and elderly people. If there are elderly people with Parkinson's disease, the impact is really great. What are the tests for Parkinson's disease? Now let's take a look.

What are the tests for Parkinson's disease?

First: imaging examination: Parkinson's disease is a degenerative disease of the central nervous system. The development of Parkinson's disease can be clearly understood through the examination of CT and MRI images. The pathological changes of Parkinson's disease are mainly in substantia nigra, striatum, globus pallidus, caudate nucleus and cerebral cortex. Therefore, in addition to general brain atrophy, basal ganglia calcification can sometimes be seen on CT images. In addition to ventriculomegaly and other signs of brain atrophy on MRI, multiple hyperintense spots were often found in basal ganglia and white matter on T2 weighted images.

Second: SPECT imaging: clinically, the etiology of Parkinson's disease is complex, and the symptoms are diverse. The examination of dopamine receptor (DAR) functional imaging is very helpful for a faster and more accurate understanding of the patient's condition. Dopamine receptors are widely distributed in the dopaminergic pathway of the central nervous system, mainly in the substantia nigra and striatum. Dar (DL) is distributed in the soma of non cholinergic interneurons in the striatum; DAR (D2) is located in the soma of dopaminergic neurons in substantia nigra and striatum.

Third: laboratory examination: (1) the activity of serum renin and the content of tyrosine decreased; The content of NE and 5-HT in substantia nigra and striatum decreased, and the activity of glutamic acid decarboxylase (GAD) decreased by 50% compared with the control group（ 2) The contents of GABA and HVA in CSF decreased significantly（ 3) . biochemical test   The content of somatostatin in CSF was decreased by radioimmunoassay. Urinary DA and its metabolites 3-methoxytyramine, 5-HT and renal a-glandulin, NE also decreased.

matters needing attention

According to the patient's age, the amount of activity to give enough total calories, diet attention to meet the supply of sugar, protein, mainly vegetable oil, less into animal fat. The protein intake should be limited in patients taking dopamine. Because protein can affect the therapeutic effect of dopamine. Protein intake is limited to less than 0.8 g per kilogram of body weight per day, and the total daily intake is about 40-50 G. High quality protein such as milk, egg, meat and bean products should be selected in the limited range. Appropriate consumption of seafood can provide high-quality protein and unsaturated fatty acids, which is conducive to the prevention and treatment of atherosclerosis