Clarithromycin Sustained Release Tablets
summary
Clarithromycin sustained release tablets are suitable for infections caused by clarithromycin sensitive microorganisms: 1. Lower respiratory tract infections: such as bronchitis, pneumonia, etc.; next, I will share with you its drug interactions.
Clarithromycin Sustained Release Tablets
First, clarithromycin increases serum concentrations of drugs metabolized by the same cytochrome P4503A (CYP3A) isoenzyme. Drugs known or suspected to be metabolized by the same CYP3A isoenzymes include alprazolam, carbamazepine, cilostazol, cyclosporin, pramipramine, ergot alkaloids, lovastatin, methylprednisolone, midazolam, omeprazole, oral anticoagulants (such as warfarin), rifabutin, sildenafil, simvastatin, tacrolimus, triazolam and vinblastine.
Second, through other isoenzymes in cytochrome P450 system. Phenytoin, theophylline and valproate also interact with each other by similar mechanisms. When combined with digoxin, the blood concentration of digoxin will increase, so it should be monitored. When HIV infected adults take clarithromycin and zidovudine orally at the same time, it will interfere with the absorption of zidovudine and reduce its steady-state blood concentration, so the medication time should be staggered. When combined with ritonavir, the Cmax, Cmin and AUC of clarithromycin were significantly increased, and the formation of 14 hydroxyclarithromycin was significantly inhibited. Therefore, clarithromycin should not be combined with ritonavir when the daily dose is more than 1G.
Third, clarithromycin is a semi synthetic macrolide antibiotic. Clarithromycin can bind to the 50S subunit of bacterial ribosome and inhibit its protein synthesis. In vitro, it has good antibacterial activity against standard strains and clinical isolates, and against a variety of aerobic and anaerobic Gram-positive or Gram-negative bacteria. Generally, the minimum inhibitory concentration (MIC) of clarithromycin is the logarithmic dilution of erythromycin. The results of in vitro pharmacodynamics showed that clarithromycin could inhibit Legionella pneumophila and Mycoplasma pneumoniae, and kill Helicobacter pylori. The activity of clarithromycin under acidic condition was stronger than that under acidic condition.
matters needing attention
All antibiotics, including macrolides, may lead to mild to life-threatening pseudomembranous enteritis; patients with liver function impairment and moderate to severe renal function impairment should be cautious; cross resistance may occur with other macrolides, lincomycin and clindamycin; the production of β - lactamase does not affect the activity of clarithromycin; most strains resistant to neopenicillin I and II are resistant to antibiotics Clarithromycin resistance.
