Negative symptoms of psychosis?

summary

The symptoms of schizophrenia are "negative" and "positive". Clinically, the onset of most patients with schizophrenia is slow and latent, and the inducement is not obvious. At the beginning, patients become increasingly isolated, not interested in everything around them, indifferent to people, and even lack feelings for their relatives. They are depressed, unresponsive, lazy, slovenly, poor in academic performance and work ability, and often in a daze or lying with their heads covered. These abnormal manifestations of "negative symptoms" are the basic symptoms of schizophrenia. Negative symptoms of psychosis? Let's talk about it.

Negative symptoms of psychosis?

Negative symptoms are independent clusters. As professor Armida mucci of Italy said, the exploration of the etiology and treatment of negative symptoms of schizophrenia is still facing great challenges. The existing researchers tend to regard negative symptoms as a whole rather than two symptom clusters with different potential diseases: lack of will and apathy, which will hinder the progress of research. The differences between the two symptom clusters can be illustrated by examples. For example, the lack of will is strongly related to the functions needed in real life, while the lack of emotion is not. The effect of willpower deficiency on function has nothing to do with social cognition, neurocognition and functional state.

Therefore, Professor mucci suggested that priority should be given to the pathophysiological mechanism and innovative treatment of volitional deficiency and its symptoms, so as to better improve the function of patients in real life.

Professor Oliver Gruber of Germany explained that "the use of neuroimaging technology to explore the potential changes of brain connections in negative symptoms of schizophrenia has yielded contradictory results." however, at present, we have found aggregate evidence of the disorder of frontal striatum thalamus, frontotemporal lobe and frontoparietal lobe network connections involved in the formation of negative symptoms, This is of great significance for future research. Therefore, it is necessary for us to study the neural network, such as animal model test by neural functional MRI technology.

matters needing attention

There is no doubt that the treatment of "defective schizophrenia" and dominant negative schizophrenia is still an unsolved problem. However, although the pathological mechanism of negative schizophrenia has been studied, Dr. bitter believes that drugs that affect D3 receptor activity may contribute to the treatment.