ANA antinuclear antibody positive what reason

summary

In clinic, many diseases are detected from the results through the corresponding examination, and antinuclear antibody positive is a common examination result when some diseases exist. Therefore, for the problem of antinuclear antibody positive, this paper will make a detailed description for you, hoping to provide help for you.

ANA antinuclear antibody positive what reason

First: antinuclear antibody, also known as anti nucleic acid antigen antibody, is a group of autoantibodies that take various components of eukaryotic cells, such as deoxyribonucleoprotein (DNP), DNA, extractable nuclear antigen (ENA) and RNA, as target antigens. It can react with the nuclei of all animals, mainly in serum, but also in pleural effusion, synovial fluid and urine.

Second, antinuclear antibodies were positive in various autoimmune diseases, such as systemic lupus erythematosus (SLE, 95% - 100%), rheumatoid arthritis (RA, 10% - 20%), mixed connective tissue disease (MCTD, 80% - 100%), Sjogren's syndrome (SS, 10% - 20%), However, after corticosteroid treatment, the positive rate can be reduced.

Third: antinuclear antibody in rheumatoid patients about 20% - 50% of IgG ana positive, rheumatoid children ana positive rate of about 19% - 35%, accompanied by iridocyclitis positive rate is high (50% - 90%), so ana positive indicates rheumatoid has the possibility of chronic ciliary inflammation. It has been found that 75% of rheumatoid patients have polymorphonuclear leukocyte specific ana or antineutrophil cytoplasmic antibody (ANCA) which can destroy the leukocytes.

matters needing attention

It can be seen from the description in this paper that the positive antinuclear antibody is a manifestation of many diseases, such as rheumatoid arthritis and Sjogren's syndrome, which are common diseases, are the results of the existence of antinuclear antibody in the human body.