How is albuminuria exceed standard to return a responsibility

summary

As an engineer in an institution, we have to have a physical examination every year. Last month, the unit had a collective examination. At the beginning of this month, the physical examination report came out, which said that I had no other diseases, but the urine protein was very high, After the doctor's treatment, it's much better. I'll share my experience with you

How is albuminuria exceed standard to return a responsibility

Reason 1: mesangial toxicity of proteinuria: in the model of renal failure, the accumulation of serum protein in glomerular mesangium can be observed. The accumulation of these macromolecular substances in mesangial area can cause mesangial cell damage and proliferation, and increase the synthesis of mesangial matrix, resulting in glomerulosclerosis.

Reason 2: the toxic effect of proteinuria on proximal convoluted tubular cells: when proteinuria occurs, the amount of protein entering the epithelial cells of renal tubules increases, which increases the activity of lysosomes, suggesting that protein causes lysosomes to overflow into the cytoplasm of tubular cells, and subsequent cell damage can stimulate inflammation and scar formation.

The third reason: the biological changes of tubular cells caused by proteinuria: many kidney diseases with proteinuria have excessive cell proliferation, which represents a non adaptive response and leads to renal failure. More and more evidences show that proteins can directly regulate the function of tubular cells, change their growth characteristics and the phenotypic expression of cytokines and matrix proteins, which can lead to the release of PDGF, FN and MCP-1 from the basal side of tubular cells and induce fibrosis.

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