Advanced symptoms of plasma cell leukemia?

summary

Plasma cell leukemia (PCL) was first reported by FOA in 1904, with incomplete statistics. More than 200 cases were reported in foreign literature, and more than 100 cases were reported in China. The number of plasma cells was more than 20%, or the absolute value of plasma cells was more than 2.0 × 109 / L, and abnormal morphology, often can diagnose PC. The data show that this disease accounts for 1% - 2% of acute leukemia, the course of disease is short, similar to other acute leukemia. At present, the overall treatment effect of PCL is not satisfactory, the treatment is difficult, and the curative effect is poor. At present, there is no good treatment option, and there is no standard treatment scheme or the best chemotherapy scheme. What about the late symptoms of plasma cell leukemia? What about it? Let's take a look at it.

Advanced symptoms of plasma cell leukemia?

First, the onset age of mm was younger, the minimum was 9 months, the median was 45.2 years old, 34.1% was less than 40 years old, while the onset age of mm was older, the median was 53 years old;

Second, the onset is acute, the symptoms are obvious, most of them are diagnosed within 2 months, rarely more than half a year; It is similar to acute leukemia in high fever, hemorrhage, enlargement of liver, spleen, lymph nodes and tenderness of sternum; There are often multiple organ infiltration, liver and spleen swelling is more common than mm;

Third: anemia and thrombocytopenia, peripheral blood leukocytes increased significantly, bone marrow hyperplasia of PPCL was significantly active, plasma cell system proliferation was significantly higher than mm, abnormal plasma cells also increased significantly; The bone damage is relatively mild.

matters needing attention

For the study of prognosis factors of patients with primary plasma cell leukemia, it is pointed out that there are two factors affecting the prognosis: one is the response to chemotherapy, if chemotherapy is effective, the survival time is longer, if there is no response, the survival time is very short; The other is chromosome karyotype. Primary plasma cell leukemia and multiple myeloma are similar, with a variety of chromosomal abnormalities and oncogene mutations. Among them, hypodiploid karyotype and chromosome 13 monomer or 13q - are closely related to poor prognosis.