What is the reason of high temperature of urine

summary

Different patients with high urine temperature may have different performance. Before looking for the cause of high uric acid, let's understand the synthesis and metabolism of uric acid. However, it should be familiar to those who know that uric acid is the end product of human purine metabolism. Unlike other mammals, human beings lack uricase in the process of evolution, and can not convert uric acid into allantoin with higher solubility and excrete it in urine. What's the reason for the high temperature of urine.

What is the reason of high temperature of urine

First: excessive intake of exogenous purine: the high content of uric acid is directly proportional to the purine content in food. 50% of RNA and 25% of DNA in food should be excreted as uric acid in urine. Strict restriction of purine intake can reduce serum uric acid content to 60 μ mol / L (1.0 mg / dl) and urinary uric acid secretion to 1.2 mmol / D (200 mg / D).

Second, endogenous purine production is excessive: endogenous purine metabolism disorder is more important than exogenous factors. The de novo synthesis of purine from noncyclic to cyclic goes through 11 steps, in which the abnormal number of enzymes will lead to excessive purine synthesis. It has been found that: 1) the activity of ribose phosphate pyrophosphate synthase is increased. 2) hypoxanthine guanine phosphoribosyl transferase deficiency. 3) glucose 6-phosphatase deficiency.

Third: increased purine metabolism: such as chronic hemolytic anemia, rhabdomyolysis, polycythemia, myeloproliferative diseases and chemotherapy or radiotherapy will produce high uric acid. Excessive exercise, epileptic state, glycogen storage disease type III, V, VII, can accelerate the degradation of muscle ATP. Myocardial infarction, smoking and acute respiratory failure are also related to the accelerated degradation of apt.

matters needing attention

Such as glucose 6-phosphatase deficiency, hereditary lactose intolerance. * alcohol also keeps uric acid in two ways. Excessive alcohol intake can accelerate the degradation of ATP and increase the production of uric acid. Alcohol induced uric acid also prevents the excretion of uric acid. Alcoholic beverages with high purine content, such as beer, are also important factors.