What are the symptoms of kidney damage caused by drugs

summary

Drug induced acute renal damage is usually manifested as ARF after a single or continuous administration for several days. Most of the patients show renal parenchymal acute renal damage. The main clinicopathological features are acute interstitial nephritis (AIN), and some of them show ATN, sometimes both of them coexist. What are the symptoms of kidney damage caused by drugs.

What are the symptoms of kidney damage caused by drugs

First, the majority of patients with kidney injury can retain the kidney through non-surgical treatment, about 74% of them are successful. After active conservative treatment and close clinical observation, most of the patients can gradually stabilize their condition, stop hematuria, reduce the mass, have fewer complications, and generally have no major sequelae. In a group of 186 cases of traumatic kidney injury, non-surgical treatment is recommended The nephrectomy rate was 3%, while the nephrectomy rate was as high as 20%.

Second: Mansi et al. Reported 108 cases of renal injury, grade III renal injury non-surgical treatment, combined with timely puncture and drainage or endoscopic treatment, not only can preserve the renal tissue, but also less late complications. The incidence of complications after renal exploration and repair is as high as 3% - 20%. Therefore, effective conservative treatment can not only reduce the nephrectomy rate, but also effectively reduce the complications.

Third: non operative treatment includes emergency treatment and general treatment. Emergency treatment includes rapid blood transfusion, infusion and resuscitation. For the patients with severe renal injury, even if the blood pressure is within the normal range, we should also take the treatment to prevent shock, and closely observe the changes of vital signs such as blood pressure and pulse, as well as the changes of abdominal mass size and hematuria color. For the patients with shock, we should carry out the necessary examination as soon as possible after the shock is corrected and in a stable condition, so as to determine the degree and scope of renal injury and facilitate the selection Choose the next treatment.

matters needing attention

① Pay close attention to the changes of vital signs. In the process of non-surgical treatment of renal injury, especially in the first week, we should closely observe the patient's blood pressure, pulse, breathing and other vital signs. ② Absolute bed rest is very important to prevent rebleeding. ③ Observe the color change of urine. If the urine turns clear gradually and the local symptoms improve gradually, the bleeding will stop. If the urine turns clear suddenly, the abdominal pain will aggravate. It may be caused by a blood clot blocking the ureter. We should not blindly think that the bleeding has stopped. ④ The size of local mass was observed. For patients with palpable mass, the scope of mass was timely marked on admission, and the change of its size was observed.