What symptom does Down's child have in abdomen

summary

Down's syndrome is a common disease in pediatrics, which is caused by chromosomal aberrations. Most children are born with this disease. If it is not controlled, the disease will change with the growth of age, which obviously causes a lot of serious harm and impact? So what causes the occurrence of children? I hope you can know more about it.

What symptom does Down's child have in abdomen

First: the pathogenic factors of late pregnancy, pregnancy toxemia, prone to placental embolism and umbilical vascular insufficiency, affect the fetal brain tissue oxygen supply. Placental or umbilical cord abnormalities, resulting in fetal blood oxygen or ischemia. Blood group incompatibility, such as Rh factor reaction, produces excessive bilirubin and amine in the fetal body, causing toxic damage. After 35 weeks of pregnancy, intrauterine fetal growth retardation is more likely to occur Down syndrome. The mother suffered from operation, infection, trauma or multiple pregnancy.

Second: postpartum factors, hyperbilirubinemia, such as neonatal hemolysis caused by nuclear yellow gangrene, brain tissue mitochondrial oxidative phosphorylation uncoupling dysfunction, brain nerve tissue energy production is insufficient and degeneration necrosis, resulting in Down's syndrome in children. Neonatal shock caused by blood loss and infection. Brain injury and epileptic convulsions affect the blood and oxygen supply of brain tissue. Brain hypoxia is caused by respiratory diseases such as atelectasis, hyaline membrane disease, pulmonary edema, intrauterine pneumonia and aspiration of gastric contents.

Third, with the increase of mother's age, the chance of children's disease is also increased. The ratio of Down's children was 1 / 2000 for mothers under 25 years old, 1 / 50 for mothers between 35 and 39 years old, and 1 / 20 for mothers over 40 years old. That is to say, after 40 years old, the probability of giving birth to Down's baby is 100 times higher than that before 25 years old. At the same time, these data also tell us that prenatal diagnosis is necessary for elderly mothers, but it is not impossible for young mothers to give birth to Down's baby. In recent years, it has been found at home and abroad that the average age of women giving birth to children has decreased, which may be related to teratogenic substances, infection and other factors. As for whether the age of men will affect the incidence rate of children, there is no conclusion.

matters needing attention

Teratogenic substances such as radiation, benzene, pesticides, and some drugs such as sulfanilamide can cause chromosome aberrations. Women who have been exposed to radiation, other teratogens, or virus infection in their abdomen before or early pregnancy are more likely to have Down's syndrome in their children. Due to genetic factors, if a female friend has ever given birth to a child with Down's syndrome, then she is more likely to be a child in the second child, which is higher than the average person.