Is AFP 17.8 normal?

summary

AFP is a glycoprotein, short for alpha fetoprotein (AFP). Under normal circumstances, AFP is mainly synthesized in the fetal liver, with a molecular weight of 69000. At 13 weeks of gestation, AFP accounts for 1 / 3 of the total plasma protein. Now I will put the related liver disease AFP 17.8 normal? Let me tell you this.

Is AFP 17.8 normal?

First, AFP is a glycoprotein, short for alpha fetoprotein (AFP). Under normal circumstances, AFP is mainly synthesized in the fetal liver, with a molecular weight of 69000. At 13 weeks of gestation, AFP accounts for 1 / 3 of the total plasma protein. The plasma concentration at birth was about 1% of the peak, about 40 mg / L, which was close to the adult level (less than 30 years old) μ mg/L)。

Second: liver cancer is one of the common causes of high AFP. The increase of alpha fetoprotein often occurs before the symptoms of liver cancer. Therefore, clinical alpha fetoprotein detection is used as an auxiliary index for the diagnosis of early liver cancer. In adults, about 80% of liver cancer patients have elevated serum AFP, and the positive rate of AFP in germ cell tumors is 50%.

Third: the content of AFP in normal people's serum is generally less than 20 micrograms per liter, so why does AFP increase? However, when the liver cells become cancerous, the function of producing this protein is restored. Therefore, if the AFP content in the blood is obviously high, the possibility of liver cancer should be considered. It can be increased 8 months before the symptoms of liver cancer appear. At this time, most patients with liver cancer still have no obvious symptoms and the tumor is small. After surgical treatment, the prognosis of these patients has been significantly improved

matters needing attention

Normal pregnant women, a small number of hepatitis and liver cirrhosis, malignant tumors of the gonad and so on often cause high AFP, but the high range is not as obvious as the high AFP caused by liver cancer. It should be differentiated when using AFP to diagnose liver cancer. It should be noted that some liver cancer AFP values are normal, so imaging examination should be performed at the same time to increase the diagnostic reliability