What are the reasons for being sensitive to pain

summary

Pain first comes from tissue damage. This produces some painful substances that stimulate the pain receptors. The stimulation of these chemicals is converted into pulses in nerve cells and transmitted to the spinal cord, brain stem, hypothalamus and brain through a δ and C nerves. There was no individual difference in the transmission of pain to the thalamus. It's the brain that determines an individual's response to pain. Let's take a look at the following.

What are the reasons for being sensitive to pain

First, when the tissues of the body are injured, whether they are bitten, burned or hit by mosquitoes, inflammation will occur. The substance causing inflammation but not pain will overflow from the tissue; even if the concentration is very low, it is enough to cause pain.

Second, prostaglandins are known as pain promoting substances; they do not cause pain, but promote inflammation. The purpose of inflammation is to increase the concentration of local leukocytes, antibodies and immune factors, protect tissues, remove wastes and make appropriate repair.

Third: there are many kinds of these substances, including amines, proteolytic substances, polypeptides, prostaglandins, hydrogen ions and so on. The function of histamine is to increase the permeability of blood vessels, make tiny pores appear in tiny blood vessels, and make white blood cells and antibodies in blood enter the tissue from blood vessels.

matters needing attention

Mechanoreceptors conduct tactile and pressure, Thermoreceptors conduct warm and cold sensation, nociceptors have high threshold to stimulation (i.e. they only respond to strong stimulation), and chemoreceptors are sensitive to the stimulation of different pain causing chemicals. After being stimulated, these receptors will pass through different nerve conduction. Mechanical nociceptive receptors are mainly transmitted through a δ nerve fibers.