What is amyloid nephropathy?

summary

Amyloid nephropathy is known as a serious kidney disease. When amyloid disease affects the kidney, it is called amyloid nephropathy. Amyloidosis is a systemic disease characterized by special protein deposition. It is a common type of plasma cell disease. Many patients do not have a correct understanding of the disease, which leads to the aggravation of the disease. The treatment of amyloid nephropathy will be more difficult. Next, to introduce the pathology of the disease, hoping to help.

What is amyloid nephropathy?

1. Amyloid nephropathy is a systemic disease that leads to structural and functional damage of multiple organs. Amyloid deposition in the kidney caused by nephropathy is called renal amyloidosis. Nephrotic syndrome is the main clinical manifestation, which can lead to renal failure and death.

2. In the early stage of the lesion, amyloid protein was deposited in the glomerular basement membrane and mesangial area, with mesangial matrix hyperplasia and irregular thickening of the basement membrane; In the middle and late stage, nodular glomerulosclerosis appeared in mesangial area.

3. Amyloid deposits were found in renal interstitium, renal tubules and renal vessels. Congo red staining was positive, orange red or brick red. Special protein deposits were observed under polarized light, showing apple green color. Due to different underlying diseases, the clinical manifestations of secondary diseases are different. There were also patients with renal involvement as the first manifestation, but systemic involvement was not obvious.

matters needing attention

The prevention of the disease should be based on the active treatment of the primary disease which can induce the disease. In recent years, tuberculosis and empyema are rare, which indicates that prevention is an effective measure. Sometimes the limited type can be resected, so the patients should choose the appropriate treatment.