How does the dry necrosis of auricle do?

summary

There are many causes of DIC. According to the analysis of a group of domestic materials, infection is the most common, accounting for more than 1 / 3 of the total number of diseases, followed by malignant tumors (including acute promyelocytic leukemia), the combination of the two accounts for about 2 / 3 of the etiology. Extensive surgery, tissue injury, obstetric accidents, cardiopulmonary bypass are also common causes of DIC.

How does the dry necrosis of auricle do?

Septicemia caused by gram-negative and positive bacteria can be caused, but Gram-negative bacteria are more common, such as Escherichia coli, proteus, Pseudomonas aeruginosa, nociceptive bacteria, etc., Gram-positive bacteria such as Staphylococcus aureus, Salmonella typhi, etc., Gram-positive bacteria such as Staphylococcus aureus, hemolytic streptococcus, Clostridium, etc. Non bacterial infection is rare, such as virus, Rickettsia, protozoa, spirochete and fungal infection. The pathogenesis of bacterial infection mainly includes the factors of bacterial infection itself and the endotoxin produced. After bacterial infection, vascular endothelial cells are damaged, and a large number of tissue factors can be released into the blood to promote blood coagulation and complement, which are also related to the activation of coagulation, fibrinolysis and kinin system.

DIC is more common in malignant tumors such as pancreas, kidney, prostate and bronchus. Acute promyelocytic leukemia is also prone to develop DIC. In cancer, DIC is particularly easy to occur in cases with extensive metastasis or a large number of tissue necrosis. This is because in these cases, tumor cells secrete a large number of mucins, tissue factors, procoagulant substances and proteolytic enzymes, which have the pathological effect of promoting coagulation and DIC.

Obstetric accidents include amniotic fluid embolism, placental abruption, hypertonic saline abortion, pregnancy toxemia, stillbirth retention, uterine rupture, cesarean section, etc. DIC can be seen. The pathogenesis is mainly due to a large number of tissue factors in amniotic fluid and placenta enter the blood circulation, promoting blood coagulation, Hypercoagulable state and abnormal changes of blood vessels and blood flow may also be the risk factors.

matters needing attention

The most important changes in the pathogenesis of DIC are caused by thrombin and fibrinolytic enzyme, which produce a lot of coagulation and fibrinolytic substances in the body. The role of the two can vary with different causes and priorities of the disease, and can also produce different changes in different phases of the disease, which should be found through a series of laboratory tests