How to get purpura
summary
My son has been coughing these days. He went to the hospital to get a bottle. When he was the first one, he coughed, and then directly caused vomiting, all phlegm. After spitting, I found several purple dots smaller than millet on my face. I rushed to see the doctor. In this instant, a large number of purple dots appeared, more and more. The doctor said that this was compressive purpura, now In the situation is also stable, so how to get purpura disease you know? Let's talk about how we got purpura.
How to get purpura
Reason 1: infection factors, the most common bacterial infection is beta hemolytic streptococcus, followed by Staphylococcus aureus, Mycobacterium tuberculosis, Salmonella typhi, pneumococcus and Pseudomonas, etc., upper respiratory tract inflammation is more common, also seen in pneumonia, tonsillitis, scarlet fever, bacillary dysentery, urinary tract infection, pustules, tuberculosis and focus infection (skin, teeth, mouth, middle ear), etc Virus infections include rubella, influenza, measles, chickenpox, mumps, hepatitis, etc. parasitic infections can also cause the disease. Ascaris lumbricoides infection is more common, and hookworm, whipworm, tapeworm, Schistosoma, vaginal Trichomonas, Plasmodium infection, etc.
The second reason is the rapid type allergic reaction. After the allergen enters the body, it combines with the protein in the body to form antigen. After a certain incubation period (5-20 days), the antigen stimulates the immune tissue and plasma cells to produce IgE. IgE is adsorbed on the mast cells (around blood vessels, stomach cavity and skin) of all organs of the body. When encountering the same antigen stimulation again, the antigen will react with the IgE adsorbed on the mast cells The mast cells can release a series of bioactive substances, such as histamine, 5-th, bradykinin, and hypersensitive slow reaction substance (SRS-A). SRS-A is composed of leukotriene C4 (LTC4) and its metabolites LTE and LTD4. LTC4 is converted to LTD4 under the action of gamma glutamyltranspeptidase, and the latter is converted to LTD4 under the action of diglutaminase Under the action of peptidase, LTE4, a series of bioactive substances, mainly act on smooth muscle, cause arteriole, capillary dilation, permeability increase, tissue, organ bleeding, edema.
The third reason is antigen antibody complex reaction, which is the main pathogenesis. Allergens stimulate plasma cells to produce IgG (also produce IgM and IgA), and the latter combines with the corresponding antigens to form antigen antibody complex. Its small molecule is soluble, which can precipitate in the blood vessel wall or glomerular basement membrane, and activate the complement system to produce C3a, C5a, C5, C6, C7, which can attract neutrophils Granulocytes, the latter phagocytize antigen antibody complexes, release lysosomal enzymes, cause vasculitis, involving the corresponding organs. In another part of immune complexes, antibodies are more than antigens, and the molecular weight of the complexes is large. They are insoluble and precipitated. They are removed by the monocyte macrophage system, and generally do not produce pathological changes.
matters needing attention
We suggest that we should pay attention to: Patients with Henoch Schonlein purpura nephritis should not eat fish. After entering the human body, the protein in fish will act as an allergen to stimulate the body to produce antibodies and release allergic substances. Generally, patients with nephropathy can bear it without allergic phenomenon, but for patients with Henoch Schonlein purpura nephritis, it will induce a series of allergic reactions. If the fish is not fresh for a long time, it will induce allergy, so special attention should be paid to it.
