Inheritance of myasthenia gravis

summary

My body has always been very good, but recently I feel muscle weakness, especially when I exercise. It's very hard to take things, which has a great impact on my work and life. The doctor said that it's myasthenia gravis. After taking the medicine for two days, I obviously feel better. Let me share with you the experience of myasthenia gravis heredity.

Inheritance of myasthenia gravis

First, the etiology of myasthenia gravis is still uncertain. Autoimmune diseases mostly occur on the basis of heredity, and heredity may be its internal cause. Among the external causes, most people think that it is related to chronic virus infection of thymus. Myasthenia gravis patients with hla-a1, A8, B8, B12, dw3, hla-b1, hla-b1, hla-b1, hla-b1, hla-b1, hla-b1, hla-b1, hla-b1, hla-b1, hla-b1, hla-b1, hla-b1, hla-b1, hla-b1, hla-b1, hla-b1, hla-b1, hla-b1, hla-b1, hla-b1, hla-b1, hla-b1, hla-b1. Most of the patients with HLA-A2 and A3 myasthenia gravis are male, and most of them have thymoma after 40 years old. The detection rate of acetylcholine receptor antibody is high.

Second, thymectomy is ineffective in some cases of myasthenia gravis, which may be due to: (1) incomplete thymectomy; (2) irreversible injury at neuromuscular junction; (3) in thymus, thymoid like effect is still caused by lymphocyte population in spleen and peripheral lymph nodes; (4) T cells around long-term survival are still active; (5) the thymic like effect is still caused by the lymphocyte population in spleen and peripheral lymph nodes; ⑤ The mechanism of heterologous disease is that each patient has different response to the influence of thymus.

Third: myasthenia gravis is a common neuromuscular disease with skeletal muscle neuromuscular junction damage, and it is also a representative autoimmune disease in neuromyopathy. The main manifestation is that the affected skeletal muscle is very easy to fatigue, and the whole body skeletal muscle can be affected, especially the extraocular muscle, which is characterized by blepharoptosis and diplopia. The symptoms of bulbar muscle involvement included eating, coughing, rigid expression, air leakage, loose mouth, unclear articulation, and in severe cases, complete inability to chew and swallow, and no expectoration. If the limbs are affected, the patient can't brush his hair and wash his face, it's difficult to lift his arms, or it's difficult to get up and squat, it's easy to fall down, it's difficult to go up and down stairs, and even his respiratory muscle is weak, and he has respiratory failure, which is life-threatening. TCM syndrome differentiation belongs to flaccidity and meat flaccidity. The main cause is due to external injury or deficiency of kidney qi of the patient's parents, resulting in congenital deficiency of essence Qi and liver loss; acquired dystrophy and weak temper.

matters needing attention

For such a disease: the distribution of affected muscles varies from person to person, extraocular muscles are the most likely to be affected, generally for the early symptoms, patients will have one or both eyelids ptosis, strabismus, attention. Patients with cold, emotional excitement, overwork, the use of anesthetics and other circumstances, easy to lead to relapse or aggravation of the disease.