What symptom does aluminous bone disease have?
summary
Aluminum often exists in food, cosmetics and pharmaceutical preparations. The daily intake of aluminum from food is about 2.5 mg, which is absorbed in small amount through gastrointestinal tract and excreted out of the body through the kidney. Due to related diseases and reasons, aluminum intake is excessive or metabolism is abnormal, resulting in a large amount of aluminum deposition in human bones, leading to aluminum bone disease, which is characterized by extensive bone and joint pain. What symptom does aluminous bone disease have?
What symptom does aluminous bone disease have?
The clinical manifestation of Al osteopathy is extensive bone and joint pain, which can be located in the back, buttocks and ribs. Proximal myasthenia, recurrent fractures are common in the ribs, femoral neck, spine and femoral shaft, and can also have the performance of bone deformation. These symptoms reflect excessive aluminum in the synovial cavity. The content of phosphorus bond in patients with aluminum was 2-10 times higher than that in patients without aluminum.
The increase of aluminum content in bone can also affect the formation of red blood cells. The clinical manifestation was reversible small cell hypochromic anemia, which could not be improved by iron supplement. The risk of diabetes is higher, which may be related to the lower bone formation rate. The bone formation rate of type 1 diabetes decreased before clinical diabetic nephropathy. The reason is unclear, but the plasma parathyroid hormone level of these patients is often low.
The content of aluminum in brain tissue is relatively low, but it can cause aluminum related encephalopathy, which was called dialysis encephalopathy or dialysis dementia in the early stage. It has been recognized that aluminum is the pathogenic factor of neurotoxin and the main cause of long-term dialysis patients complicated with nervous system syndrome. Early performance for intermittent language disorders (stuttering), use disorders. In the late stage, the symptoms were persistent language disorder, flapping wing tremor, myoclonus, epilepsy, personality change, thinking disorder, disorientation, progressive dementia and aphasia.
matters needing attention
Once the diagnosis is established, aluminum containing agents, such as aluminum containing phosphate binders, human serum albumin (albumin) and high nutritional supplements, should be stopped. Check the source of aluminum contamination, such as the content of aluminum in dialysate. The disease is mainly seen in patients with end-stage renal disease, aluminum bone disease with deferoxamine treatment can quickly obtain clinical curative effect. But the side effect is also obvious, mucormycosis can appear. 30% of patients have known risk factors (diabetes, leukemia or immunosuppressive agents) for this fungal infection. 44% of the patients had diffuse lesions and 31% had nasal brain involvement.
