What is gigantism and acromegaly?

summary

This disease is caused by excessive secretion of growth hormone by the anterior pituitary. Giant's disease occurs before puberty when the epiphysis is not fused; Acromegaly occurs after puberty when the epiphysis has fused. The cause of the disease is growth hormone cell adenoma or hyperplasia in the anterior pituitary. The clinical manifestations were rapid growth, facial deformation, large nose, large tongue, prominent cheekbones and mandible, and acromegaly. It is the third in pituitary adenoma. The ratio of male to female is 1.3-2.2:1. The diagnosis can be made by the determination of growth hormone and location examination. The treatment method should be surgery, radiotherapy or drugs according to the specific condition. What is gigantism and acromegaly?

What is gigantism and acromegaly?

The results are as follows: 1. Gigantism is characterized by rapid growth of trunk and viscera, strong sexual desire in the formative stage, low spirits, fatigue, back rickets, impotence and dullness in the declining stage; 2. Headache, vision loss, visual field defect, polydipsia, polyuria;

2. Special features: enlarged mandible, prominent eyebrow arch and cheekbones, thick lips, big nose, big tongue, rough face and thick skin; The extremities of hands and feet are hypertrophic. Giant's disease grows too fast in its formative stage. It can reach a tall adult at the age of 10 and has strong sexual desire. In the late period of decline, the spirit is withered, weak, impotent and dull.

5. The serum growth hormone (GH) did not change or increased in TRH test. In L-dopa test, serum GH decreased. The increase of GH in CSF indicates that the tumor has developed to suprasellar region. The brain tumor was identified as growth hormone tumor by electron microscopy and immunocytochemistry.

matters needing attention

This disease is caused by prolapse adenoma or hyperplasia. In terms of treatment, young people take surgery, supplemented by radiotherapy and drugs. Small adenoma is more common in middle-aged and elderly people. Drug therapy and radiotherapy can be used first, and surgery can be performed if necessary.