How does lupus nephritis immune preparation decrement

summary

For lupus nephritis patients, they need to rely on immune agents for better treatment. Over time, patients will become drug dependent. We all know that taking too many drugs can cause harm to the body, so we must reduce the dosage appropriately. Let's talk about how to reduce the dosage of lupus nephritis immune agents.

How does lupus nephritis immune preparation decrement

First, the principle of steroid therapy for lupus nephritis is sufficient, slow reduction and long-term maintenance. Adequate dose, 1mg / kg / D, 40mg or more are considered adequate, generally the maximum dose is 60mg. If the dosage is too large, the side effects will increase, but the curative effect is not prominent. Generally, it is taken for 12 weeks. Slow down, 1 / 10 every 2-3 weeks. Specifically, 5mg can be reduced every 3 weeks or so, or every 2 weeks or every 4 weeks, depending on whether the patient has repeated attacks; 2.5mg can be reduced at the same time interval for patients below 20mg. 　　

Second: long term maintenance, maintenance is generally 20mg every other day or 10mg every day; maintenance for 3-5 years or more. 20mg every other day or 10mg every other day is the physiological amount of adrenal cortisol, which has little side effect and is effective for clinical patients. Cyclophosphamide was given orally 100 mg daily or intravenously 200 mg every other day, and stopped when the cumulative dose reached 6-8 g or 8-12 G. 　　

Third: the initial dose of cyclosporine a must be small, 4-5mg / kg / D is appropriate; take it orally in two times, the valley value must be monitored, and the valley value of blood concentration must be maintained at 100-200ng / ml; gradually reduce the dosage after taking it for 3 months, and then stop taking it for 3-6 months. Cyclosporine A has some side effects, such as hepatorenal toxicity and hypertension. Reducing initial dose and taking dihydropyridine calcium channel blocker can prevent acute nephrotoxicity.

matters needing attention

It's impossible to reduce the amount all at once. If you want to reduce it properly every day, the dependence will be weakened after a long time. According to the doctor's advice, appropriate reduction will not affect the recovery of our patients, any antibiotics may contain hormones, so if people take too much, it will affect the normal regulation of other functions of our body.