What are the steps of autologous bone marrow transplantation

summary

The only way to cure leukemia is bone marrow transplantation. Sometimes it can be autologous bone marrow transplantation. A friend just finished the operation and explained the steps of autologous bone marrow transplantation to you.

What are the steps of autologous bone marrow transplantation

First of all, autologous bone marrow transplantation is to collect bone marrow samples from patients for autologous transplantation. Although the well-known allogeneic transplantation has a good effect on acute leukemia, it is limited in clinical application due to the lack of suitable marrow donors and the high cost of transplantation. There are very few people who can have bone marrow transplantation, mostly because of the price. The cost of leukemia is very high.

Secondly, bone marrow infusion (1) autologous bone marrow reinfusion on the same day, such as deep hypothermia preservation of bone marrow cell lines, should be rapidly thawed in 40 ℃ water bath before reinfusion. (2) Dexamethasone 5mg was injected intravenously before bone marrow infusion. (3) Start total parenteral nutrition.

Finally, postoperative treatment (1) low molecular dextran 500 ml / D was given intravenously for 3 days from the first day after operation. (2) After 24 hours of chemotherapy pretreatment, hemopoietic growth factor (G-CSF or GM-CSF) 150-300 μ g / D could be injected subcutaneously until the total number of white blood cells reached 1. Above 0 × 10 / L. (3) If the platelet count is lower than 20 × 10 / L, platelet suspension should be infused. (4) Blood products should be irradiated by 25Gy before transfusion.

matters needing attention

Patients with immunodeficiency infection after transplantation are in a state of severe agranulocytosis and immunodeficiency. Agranulocytosis is the most prominent one month after transplantation. Bacterial infection is the most common in this stage, especially gram-negative bacilli sepsis. Fungal infection can also occur. To maintain a good mood, even if there is no appropriate bone marrow, but also to a good life, and to develop good habits.