Nephrotic damage

summary

Chronic nephritis is generally early detection, early treatment effect will be very good, general chronic nephritis is difficult to cure, only clinical cure. Now I'd like to share some information about the harm of kidney disease.

Nephrotic damage

First: it can lead to renal tubular dysfunction: renal tubular dysfunction of nephrotic syndrome, especially in children. The mechanism is that the renal tubule reabsorbs the filtration protein and damages the tubular epithelial cells. It is often manifested as diabetes, amino acid urine, hyperphosphatemia, renal tubular potassium loss and Hyperchloric acidosis. The occurrence of multiple renal tubular dysfunction often indicates poor prognosis.

Second, it can lead to abnormal bone and calcium metabolism: nephrotic syndrome is often characterized by hypocalcemia, and sometimes fibrocystic osteitis caused by osteomalacia and hyperparathyroidism. In the progression of nephrotic syndrome, osteodystrophy is more serious than advanced renal failure and toxicosis.

Third: cause coronary heart disease: it has been reported that the incidence of myocardial infarction in patients with nephrotic syndrome is 8 times higher than that in normal people. Coronary heart disease has become the third cause of death in nephrotic syndrome (after infection and renal failure).

matters needing attention

Due to the hypoalbuminemia of nephrotic syndrome, a large amount of plasma protein is excreted from the urine, and the human body is in the state of protein malnutrition due to the decrease of protein, which promotes the ability of the liver to synthesize albumin. If enough protein and heat can be given in the diet, the patient can synthesize albumin up to 22.6 g per day, which can effectively alleviate the negative nitrogen balance and improve the hypoalbuminemia It is generally advocated that the daily protein intake of patients should be 1 g / kg body weight, plus the protein lost in daily urine.