What causes vitiligo

summary

I am a patient with leukoplakia, white spots in my neck position, relatively smooth. What causes vitiligo? Do you know anything about this? So let's talk about the causes of vitiligo.

What causes vitiligo

First: vitiligo is a common acquired localized or generalized skin depigmentation disease. However, the mechanism is still unclear. It can occur in all parts of the body, common in finger back, wrist, forearm, face, neck and around genitalia. The decrease of copper or ceruloplasmin levels in the blood and skin of patients with vitiligo leads to the decrease of tyrosinase activity, which affects the metabolism of melanin.

Second: female vulva can also occur, young women in the majority. Vitiligo can appear in twins and families, indicating that heredity plays an important role in the pathogenesis of vitiligo. Studies have shown that vitiligo has incomplete penetrance and multiple pathogenic loci. Vitiligo can be combined with autoimmune diseases, such as thyroid disease, diabetes, chronic adrenal insufficiency, pernicious anemia, rheumatoid arthritis, malignant melanoma and so on.

Third: mental factors are closely related to the onset of vitiligo. Most patients have mental trauma, excessive tension, depression or depression at the onset or skin lesion development stage. The degeneration of nerve endings in leukoplakia also supports the neurochemical theory. Antibodies and T lymphocytes can be produced in patients with vitiligo, indicating that the immune response may lead to the destruction of melanocytes.

matters needing attention

We need to understand the symptoms of segmental vitiligo. When the onset of segmental vitiligo, white spots for one or several pieces, along the skin area dominated by the skin ganglion segment to the distribution, generally unilateral onset, these characteristics are clinically different from the important signs of vitiligo vulgaris, other symptoms are similar to most of the symptoms of vitiligo. In general, patients with segmental vitiligo will have different degrees of immune system dysfunction, local skin microcirculation disorders and other symptoms. These lesions have a direct causal relationship with the habits of patients in daily life.