Can antinuclear antibody positive die?

summary

Antinuclear antibody is an item in the serum test. If it is positive, it is likely to suffer from rheumatoid arthritis, systemic scleroderma, Sjogren's syndrome and other diseases, mostly in the elderly. Experts remind that if antinuclear antibody positive flowers are found in blood tests, they must be checked and treated correctly according to their actual situation. Can antinuclear antibody positive die?

Can antinuclear antibody positive die?

ANA has important diagnostic value for many autoimmune diseases. ANA is most common in systemic lupus erythematosus and mixed connective tissue disease. In rheumatoid arthritis, Sjogren's syndrome, systemic scleroderma can also appear positive. And low titer of ANA can be found in chronic active hepatitis, tuberculosis, myasthenia gravis, chronic thyroiditis, and can also be detected in the normal elderly. Many patients take the test report, do not understand the karyotype of each antinuclear antibody, but generally speaking, Ana titer greater than 1:80, positive people should highly suspect autoimmune disease, and the higher the titer.

In clinical practice, first of all, a preliminary screening test should be carried out to determine whether ana is positive in patients' serum, and then each subclass of ANA should be further detected. Indirect immunofluorescence is the standard screening method for ana. The positive results of ANA can be reported as homogeneous type, spotted type, nucleolar type, centromere type and so on. The determination of different karyotypes has important reference value for the next step of detection and clinical diagnosis.

Antinuclear antibody is the general name of a large class of autoantibodies. Ana positive can be further classified into autoantibodies specific to a variety of nuclear antigen components. According to the fluorescence model of indirect immunofluorescence (the antigen substrate is Hep-2 and liver slice), different fluorescent karyotypes can be distinguished, and different karyotypes also have differential significance. For example, SLE is mostly homogeneous.

matters needing attention

It is more valuable to understand the autoantibody spectrum of different connective tissue diseases first and then combine with clinical manifestations. After the diagnosis of ANA positive antinuclear antibody, in the process of ANA positive antinuclear antibody, patients must actively cooperate, do not cooperate, they will not have a good understanding of their own problems, especially for the elderly, we should pay attention to this point, and after the diagnosis, we can consult where we do not understand.