How to diagnose and differentiate hepatoblastoma in children?

summary

Hepatoblastoma in children is a malignant tumor of liver, spleen and tissue. It mostly occurs in infants under three years old. Its clinical characteristics are gradually enlarged abdomen, palpable mass in upper abdomen, loss of appetite, emaciation, anemia and so on. Jaundice and ascites will appear in the late stage, according to the clinical manifestations and laboratory, auxiliary examination results confirmed. How to diagnose and differentiate hepatoblastoma in children? Now let me tell you something.

How to diagnose and differentiate hepatoblastoma in children?

The exact cause of hepatoblastoma in children is unknown. It has been reported that the incidence of Hb is related to fetal alcoholism or mother's oral contraceptives. In addition, some scholars believe that the pathogenesis of pediatric hepatoblastoma may be related to the homozygous variation of 11p allele.

At the beginning of the disease, the general symptoms are not obvious, there is no jaundice or fever, visible abdominal fullness, occasionally found by parents, sometimes in the health examination, the doctor found abdominal mass, slightly older children can complain of abdominal pain. Sometimes, liver cancer cells may produce gonadotropin, which makes children have precocious puberty.

There are individual children see skin pigmentation, some children do not feel abdominal pain, the course of disease is general, malignant tumor progress rapidly, anorexia, progressive weight loss. Late fever, secondary anemia, ascites and lower extremity edema, occasionally upper gastrointestinal bleeding and jaundice

matters needing attention

Many biochemical substances, such as protein and lipid, are produced by the liver or metabolized in the liver. Therefore, it is necessary to study cholesterol, even if the examination of dehydrogenase, albumin globulin, alkaline phosphatase, bilirubin and so on can reflect the liver function. Serum alkaline phosphatase is often increased, which is helpful for the diagnosis of liver cancer.