Symptoms of high aldosterone edema

summary

Proaldehyde * refers to the excessive secretion of aldosterone in the adrenal cortex, resulting in sodium retention, potassium excretion, increased blood volume, and inhibition of renin angiotensin system activity. The main clinical manifestation was hypertension with hypokalemia. There are five types of primary aldosteronism: aldosteronoma, idiopathic aldosteronism, primary adrenal hyperplasia, familial aldosteronism, adrenocortical carcinoma secreting aldosterone, ectopic aldosterone secreting tumor or carcinoma. Studies have found that aldosterone is an important risk factor for cardiac hypertrophy, heart failure and renal function damage. Compared with the patients with essential hypertension, the damage of target organs such as heart and kidney in patients with primary aldosteronism is more serious. Therefore, early diagnosis and treatment is very important. Aldosterone high symptom edema? Let's talk about it

Symptoms of high aldosterone edema

Hypertension is the earliest symptom. The blood pressure of most patients increased significantly, but malignant hypertension was rare. Primary hyperaldosteronism (PA) may be associated with refractory hypertension, which is defined as the failure of blood pressure (BP) to meet the standard even after the use of appropriate diuretics. But very few patients may not have hypertension. 　

Myasthenia and periodic paralysis are common. Generally speaking, the lower the blood potassium, the more serious the muscle involvement. It is common to induce fatigue, or take diuretics such as hydrochlorothiazide and furosemide to promote potassium excretion, but most of them are not obvious.

Due to a large amount of potassium loss, the epithelial cells of renal tubules are vacuolated and deformed, the function of concentration is decreased, accompanied by polyuria, especially nocturia, secondary thirst and polydipsia, which are often complicated with urinary tract infection. Urinary protein increased, a small number of renal dysfunction. 　

matters needing attention

It is recommended that the first choice of drug treatment for idiopathic aldehydes. Spironolactone is recommended as the first-line drug and eplerenone as the second-line drug. Low dose glucocorticoid is recommended as the first choice for the treatment of glucocorticoid inhibitive aldosteronism.