What diseases can hyperlipoproteinemia type I cause?

summary

Hyperlipoproteinemia type I (exogenous hypertriglyceridemia, familial fat induced hyperlipidemia and chylomicronemia) is a relatively rare hereditary disease, which is caused by the dysfunction of lipoprotein lipase or apo - Ⅱ, resulting in the decrease of chylomicrone, VLDL and triglyceride clearance from the blood. What diseases can hyperlipoproteinemia type I cause?

What diseases can hyperlipoproteinemia type I cause?

The clinical manifestations of hyperlipidemia mainly include two aspects: one is xanthoma caused by lipid deposition in dermis; On the other hand, atherosclerosis caused by lipid deposition in vascular endothelium leads to coronary heart disease and peripheral vascular disease. Because the incidence of xanthoma in hyperlipidemia is not very high, the occurrence and development of atherosclerosis takes quite a long time, so most patients with hyperlipidemia do not have any symptoms and abnormal signs.

Carotid and cerebral atherosclerosis is most common in the beginning of internal carotid artery, basilar artery, middle cerebral artery and Willis ring fibrous plaques and atherosclerotic plaques, often lead to lumen stenosis, and can be aggravated or even formed occlusion due to complex lesions. Brain parenchyma atrophy can be caused by long-term blood supply deficiency. Patients may have mental and memory impairment, psychosis, and even dementia. Rapid interruption of blood supply can lead to cerebral infarction (encephalomalacia) and rupture of small aneurysms, which can cause cerebral hemorrhage and corresponding clinical manifestations.

Atherosclerotic lesions of the kidney usually involve the opening of the renal artery and the proximal end of the main artery, as well as interlobar artery and arcuate artery. Intractable renovascular hypertension is often caused by stenosis of lumen caused by plaque; It can also cause renal tissue infarction due to plaque combined with thrombosis, causing renal pain, anuria and fever. As pyknosis kidney is characterized by large scar left after the infarction focus is organized, and multiple scars can cause the kidney to shrink.

matters needing attention

Through a variety of ways to carry out extensive and repeated health education, advocate scientific diet, balanced diet, regular physical exercise, prevent obesity, quit smoking, alcohol, and combine with health publicity and education of prevention and treatment of cardiovascular disease, obesity, diabetes and other chronic diseases, so as to keep the blood lipid in the population at an appropriate level. In addition, regular health examination is also helpful to detect dyslipidemia as soon as possible, and timely treatment should be carried out.