Why do children have polycystic kidney

summary

Polycystic kidney was found in April 2009 and was removed on May 12. We did six courses of chemotherapy from June to October, but now we have a certain degree of control of the disease through treatment. I'll tell you why children have polycystic kidney disease.

Why do children have polycystic kidney

First: scientifically speaking, polycystic kidney is one of the most common congenital cystic nephropathy, which belongs to a special case of renal cyst. Because polycystic kidney is a congenital disease, it is a congenital inheritance of kidney.

Second: generally, the way of inheritance is autosomal dominant inheritance and autosomal recessive inheritance. Autosomal recessive polycystic kidney, also known as infantile or infantile polycystic kidney, is a rare disease. 75% of the children died within hours to days after delivery. The 15-year survival rate of patients over the neonatal period is 50% - 80%.

Third: the cause of polycystic kidney disease is gene deletion. Among them, adult polycystic kidney is often due to the gene deletion of chromosome 16, occasionally due to the gene deletion of chromosome 4, which is a dominant inheritance with 100% penetrance. Therefore, the chromosome deletion of a single parent will make its children have 50% possibility to inherit the disease. Infantile polycystic kidney disease is an autosomal recessive inheritance. Only when both parents have the genetic change of the disease can their children get the disease. The incidence rate is 25%.

matters needing attention

The cause of polycystic kidney disease is gene deletion. Adult polycystic kidney disease is often due to the gene deletion of chromosome 16, occasionally due to the gene deletion of chromosome 4, which is a dominant inheritance with 100% penetrance. Therefore, the chromosome deletion of a single parent will make its children have 50% possibility of inheriting the disease. Infantile polycystic kidney disease is an autosomal recessive inheritance, and both parents have the gene of the disease Change can make their children sick, the incidence rate is 25%.