What is the effect of clotrimazole suppository

summary

In clinical practice, for female vaginal parts caused by Candida infection, can be treated by taking clotrimazole suppository. Therefore, the next part of this article will tell you about the effect of clotrimazole suppository.

What is the effect of clotrimazole suppository

First of all, clotrimazole is a pyrrole antifungal drug in clotrimazole suppository, which can inhibit the transformation of Candida albicans from spores to invasive hyphae.

Secondly, clotrimazole has broad-spectrum antifungal activity. It has good antibacterial activity against dermatophytes, Trichophyton, Aspergillus, chromophoric fungi, Cryptococcus and Candida. It also has certain antibacterial activity against Sporothrix schenckii, Blastomyces dermatitis, coccidiospora and histoplasmosis. The effects of clotrimazole, Aspergillus, some phaeosporaceae and Mucor are poor.

Finally: clotrimazole in clotrimazole suppository can inhibit the biosynthesis of ergosterol and other sterols by interfering with the activity of cytochrome P-450, damage the fungal cell membrane and change its permeability, resulting in the leakage of important intracellular substances; it can inhibit the biosynthesis of triglyceride and phospholipid of fungi; It can also inhibit the activities of oxidase and peroxidase, cause the accumulation of hydrogen peroxide in cells, and lead to the degeneration of cell SUBMICROSTRUCTURE and cell necrosis. Clinically, it is also suitable for vulvovaginitis, paronychia and tinea versicolor caused by Candida albicans infection.

matters needing attention

In the role of clotrimazole suppository with a preliminary understanding, we should also pay attention to avoid menstrual period when taking this drug.