How does esophagus leukoplakia form?

Update Date: 2025-09-04 Source: Network

summary

Esophageal leukoplakia is relatively rare. It is a precancerous lesion. It has been reported that the malignant transformation rate is up to 5%. It can be used as a local manifestation of mucosal leukoplakia or a disease limited to esophagus. Now I would like to share with you about the formation of esophageal leukoplakia? Experience in this area.

How does esophagus leukoplakia form?

First, esophageal leukoplakia is mainly caused by mucosal hyperkeratosis. Any long-term persistent stimulatory factors, such as tobacco and alcohol, spicy food and overheated diet, as well as oral hygiene, are the causes of mucosal hyperkeratosis.

Second: all the long-term persistent stimulating factors, such as strong tobacco and alcohol, spicy food and overheated diet, as well as oral hygiene, are the causes of mucosal hyperkeratosis. In addition, such as anemia, endocrine disorders, cirrhosis, systemic progressive sclerosis, fungal infection and other factors can also affect the normal keratinization process.

Third, hyperkeratosis and dyskeratosis of the epithelial layer, thickening of the acanthocyte layer, extensive edema inside and outside the acanthocytes, breaking of intracellular connections, and mild infiltration of inflammatory cells in the dermis. At autopsy, there was diffuse leukoplakia in the whole esophagus, like white bark, involving the whole esophagus. Or sporadic leukoplakia was patch or plaque. Endoscopy showed that the esophageal mucosa was white or scattered white plaque, which was higher or slightly higher than the normal mucosa. Between the leukoplakia is the normal mucosa. Biopsy showed that some leukoplakia showed spinous cell thickening and contained a lot of glycogen. Therefore, this kind of mucosal leukoplakia is also called glycogenic acanthosis. Biopsy can also exclude fungi, cancer and other diseases.

matters needing attention

Generally speaking, the prognosis of patients with esophageal leukoplakia is good. In addition, patients need to pay attention to their own eating habits, such as avoiding raw, hot, cold and spicy food, and giving up smoking and drinking less or no alcohol.